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Background: Oleanolic acid(OA)and its isomer ursolic acid(UA)have recently emerged as research foci based on their biologic activities.We previously demonstrated that UA can inhibit the activities of UGT1A3 and UGT1A4,and OA impedes UGT1A3 activity in liver microsomes.However,whether OA and UA affect the expression of UGT1As in HepG2 cells and the underlying regulatory mechanism remain unclear.