【摘 要】
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The mechanisms of astrovirus pathogenesis are largely unknown, in part due to a lack of a small-animal model of disease.Using shotgun sequencing and a custom analysis pipeline, we identified two novel
【机 构】
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Department of Pathology and Immunology,Washington University School of Medicine, St.Louis, Missouri,
【出 处】
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中国免疫学会第九届全国免疫学学术大会
论文部分内容阅读
The mechanisms of astrovirus pathogenesis are largely unknown, in part due to a lack of a small-animal model of disease.Using shotgun sequencing and a custom analysis pipeline, we identified two novel astroviruses capable of infecting research mice, murine astrovirus (MuAstV) STL1 and STL2.Subsequent analysis revealed the presence of at least two additional viruses (MuAstV STL3 and STL4), suggestive of a diverse population of murine astroviruses in research mice.
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