New Delhi metallo-β-lactmase-1(NDM-1)catalyzes the hydrolysis of β-lactam antibiotics and cleaves the β-lactam ring of the molecule,conferring resistance against these medicines to bacteria.
Accelerated proliferation of cancer cells is linked to increased transcription of rDNA by RNA polymerase I(Pol I)to produce elevated levels of rRNA for ribosomal biogenesis.
The continued emergence of drug-resistant pathogens is a global public health problem.With the increasing antibiotic resistance of bacteria,there is an obvious need for alternative therapeutics and ma
Drug-resistant bacteria pose an urgent public-health crisis.Over the years,β-lactams were the antibiotics of choice for treatment of S.aureus infections1.
β-Lactam antibiotics are widely used in the treatment of bacterial infections.However,The overuse of antibiotics leads to the emergence of drug-resistant bacteria,which has posed a great threat to hum
The drug-resistant bacteria have been a serious threat to the clinical treatment.These bacteria hydrolyze almost all β-lactam antibiotics by expressing the metallo-β-lactamses(MβLs).
Non-alcoholic fatty liver disease(NAFLD)is the hepatic manifestation of obesity and metabolic syndrome,which encompasses a histological spectrum ranging from simple steatosis to nonalcoholic steatohep