PKR(double-stranded RNA-dependent protein kinase)and PKZ(protein kinase containing Z-DNA binding domain)are two important members of eIF2α kinase family.
Interferon regulatory factor(IRF)10 was first found in birds and is present in the genome of other tetrapods(but not humans and mice),as well as in teleost fish.
The protein kinase R(PKR)can inhibit protein translation and lead to apoptosis under the circumstances of virus invasion and multiple other stress conditions.
Interleukin-1β(IL-1β)is the prototypic pro-inflammatory cytokine,whose functions are mediated through interaction with its receptors(IL-1R1 and IL-1R2).