ArgR as a Novel Therapeutic Target against MRSA By 4-hydroxycoumarin Derivatives

来源 :中国药理学会第十三届全国化疗药理学术研讨会 | 被引量 : 0次 | 上传用户：wuwei72323

【摘要】

：

【作者】

：

Di Qu Liyang Luo Jing Li Ying Zhou Jingru Meng Xiaoyan Xue Bo Ma Zhi Li Xiaoxing Luo Mingkai Li

【机构】

：

Department of Pharmacology, School of Pharmacy, the Fourth Military Medical University, Xi'an China

【出处】

：

中国药理学会第十三届全国化疗药理学术研讨会

【发表日期】

：

2016年4期

【关键词】

：

Staphylococcus aureus MRSA coumarin MIC biofilm arginine

下载到本地 , 更方便阅读

下载此文赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

　　Objectives:The increasing prevalence of drug-resistant Staphylococcus aureus (S. aureus) infection demands the development of new antibacterial agents. We aimed to study the in vitro and in vivo anti-S aureus activity of novel comarin derivatives, and explore the mechanism of these compounds.

其他文献

Preparation and characterization of safflower flavonoid extract Dripping pills and its transport mec

Kaempferol-3-O-rutinoside(K3R)andanhydrosafflor yellow B from safflower,have neuroprotective effect.In this study,we prepared pills from safflower flavonoids extracts and excipients by heating and mel

会议

Safflowerkaempferol-3-O-rutinosidepillsParkinson's diseaseCaco-2 cell m

Preparation and release behavior of sustained release desvenlafaxine succinate pellets

OBJECTIVE Our study aimed to prepare sustained-release desvenlafaxine succinate(DVS)pellets coated with aqueous ethylcellulose dispersion(Surelease(R))and to investigate their drug release behavior.

会议

Desvenlafaxine succinateEthylcellulose aqueous dispersionSustained-release pel

The Enantioseperation and Optical Stability with Ultron ES-CD Optical Column in Epotastine Besilate

会议

RGD conjugated liposome-hollow silica hybrid nanovehicles for targeted and controlled delivery of ar

Targeted delivery and controlled drug releasing are two strategies to enhance the anticancer effect of arsenic trioxide(ATO)which was hampered by its poor pharmacokinetics(PK)and dose-limited toxicity

会议

arsenic trioxidehollow mesoporous silica nanoparticlesliposomal shellArg-Gly-

Polyethylene-polyglutamine as a gene carrier delivering MDR1 siRNA to A549/DDP cells for reversal of

A major problem in cancer chemotherapy is the development of multidrug resistance(MDR)by tumour cells.In recent years,RNAi-based technology holds enormous potential beyond a laboratory to the clinic.R

会议

multidrug resistancesiRNA deliverycationic polymerMDR1cisplatin

Lipid nanovehicles with adjustable surface properties for overcoming multiple barriers simultaneousl

Lipid nanoparticles(LNs)have been widely investigated in oral drug delivery,displaying dramatic advantages in colloidal stability,biocompability and scaling-up.However,how to further elevate the abili

会议

Lipid nanoparticleshydrophobic substitutesmucus barrierepithelium barrier

Core-shell mesoporous silica NPs based nanohybrid with sequential detachment of HPMA co-polymers for

Cationic materials have been reported as promising tools for targeting to mitochondria which are the "power houses" and "metabolic garbage keepers" of cells.However,the positive nature also restricts

会议

Near Infrared Light Responsive Hybrid Nanoparticles for Synergistic Cancer Therapy

A near infrared(NIR)light responsive chromophore 7-(diethylamino)-4-(hydroxymethyl)-2H-chromen-2-one(DEACM)was synthesized and incorporated to β-cyclodextrins with cRGD functionalized poly(ethylene gl

会议

Metabolic kinetics and inhibition of ampelopsin by pharmaceutical excipientsin rat liver microsomes

Ampelopsin(AMP)is the major active constituent of the traditional Chinese medicine Ampelopsis grossedentata(Hand-Mazz)W.T.Wang.Recently it has been reported to possess numerous pharmacological activit

会议

AmpelopsinPharmaceutical excipientsMetabolic kineticsInhibition of hepatic me

食品动物源大肠杆菌中blaCTX-M-55质粒流行特点的研究

目的：研究不同时间和来源大肠杆菌中携带blaCTX-M-55基因的质粒特点,探究blaCTX-M-55在国内传播广泛的原因.方法：选取实验室保存的2006年至2014年间携带blaCTX-M-55基因的接合子、转化子共104株,采用PCR方法对质粒进行复制子分型并检测其他耐药基因(fosA3、rmtB、floR和mcr-1),采用S1-PFGE和Southern杂交的方法测定质粒的大小.结果：10

会议

大肠杆菌blaCTX-M-55质粒

ArgR as a Novel Therapeutic Target against MRSA By 4-hydroxycoumarin Derivatives

其他学术论文