【摘 要】
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We report a simple andgreen strategy for the preparation anddrug loading and release properties ofthe drug delivery system consisting ofcalcium phosphate (CP) nano-carriersand dual-loaded bovine serum
【机 构】
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State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of
【出 处】
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2012上海市研究生学术论坛暨第三届上海交通大学医(理)工研究生学术论坛
论文部分内容阅读
We report a simple andgreen strategy for the preparation anddrug loading and release properties ofthe drug delivery system consisting ofcalcium phosphate (CP) nano-carriersand dual-loaded bovine serum albumin(BSA) and hydrophobic drug ibuprofen(IBU). The sequential loading of BSAand IBU in calcium phosphate nanocarriersand in vitro simultaneousrelease of BSA and IBU are realizedand investigated. In this method, BSA, is in-situ encapsulated in calciumphosphate nano-carriers, andsubsequently a typical hydrophobicdrug IBU is loaded in the BSA/CP drugdelivery system, forming theIBU/BSA/CP dual-drug deliverysystem. The experiments reveal that the preloaded BSA not only reduces thecytotoxicity of calcium phosphatenano-carriers but also significantlyimproves the IBU drug loadingcapacity in calcium phosphate nanocarriersand greatly extends theduration of drug release. Thus, the aspreparedIBU/BSA/CP dual-drugdelivery system is promising for drugdelivery applications.
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