Aberrant synapse plasticity of motor cortex for learning disabilities in Parkinson's disease mi

来源 :The 6th FAONS Congress and 11th Biennial Conference of CNS(第 | 被引量 : 0次 | 上传用户:mynewgolvoe
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
  Parkinsons disease(PD)is the second most common neurodegenerative disease,a condition characterized by deficits in both fine movement control and motor learning.The loss of midbrain dopaminergic neurons is the hallmark of PD.
其他文献
Gap junctions(GJ)play an important role in intercellular communication between adjacent cells.The protein expression,membrane cluster,subtype couple,pore selectivity and gating of GJs might be regulat
Auditory cortical neurons exhibit relatively large variation in their spiking responses to sound stimuli,reflected in the reliability of the response and the precision of the spike timing.The present
Objective: To study the distribute and nature of the lipid droplets within Hensens Cells(HCs)of guinea-pig Cotis organ; by Bodipy 493/503: one of the flurescent molecular probes for staining fats.
The olfactory system is important for mammals.Experimental approaches suggested that the glomeruli in the main olfactory bulb present a special map to odor stimuli.Although the same species share simi
Objective Itch has a significant negative impact on an individuals quality of life.However,the molecular mechanisms underlying itch processing in the spinal cord remain largely unknown.Methods pERK st
Neuropathic pain is difficult to treat in clinic because of insufficient understandings of its mechanisms.Except for peripheral sensitization from injury and inflammation,central sensitization plays a
Objective Pain is one of the most severe symptoms in bone cancer patients.Previous studies have suggested that the activation of spinal microglia is necessary for the development of inflammatory and n
Cholinergic modulation is essential for frequency-specific plasticity of the central auditory system arising from learning and experience.Activation of cholinergic nuclei,such as the nucleus basalis i
Objective Hydrogen sulfide(H2S)contributes to visceral hyperalgesia in primary sensory neurons,but its role in central nerve system is not well known.This study is to investigate whether H2S and its e
Objective To observe the effect of high frequency repetitive transcranial magnetic stimulation(rTMS)on the cognitive behavior and hippocampal synaptic plasticity in aged mice.Methods 45 Kunming mice(1