GP联合紫杉醇对胃癌细胞的协同抑制作用及其机制

来源 :全国药物化学学术会议暨第四届中英药物化学学术会议 | 被引量 : 0次 | 上传用户：zjl658788

【摘要】

：

目的：探索新型冬凌草甲素衍生物GP 与紫杉醇(Paclitaxel,PTX)对人胃癌MGC 803细胞的协同抑制作用及其分子机制。方法：MTT 法检测GP 与PTX 联用对MGC803 细胞的增殖抑制作用,并利用中效法则(Talalay-Chou Method)计算联用指数(Combination index,CI),评价GP 与PTX 联用的效果；流式细胞术检测GP 或(和)PTX 作用后MGC

【作者】

：

王赛琪姜利平王冉窦银慧刘宏民

【机构】

：

郑州大学药学院新药研究开发中心河南郑州 450001

【出处】

：

全国药物化学学术会议暨第四届中英药物化学学术会议

【发表日期】

：

2013年11期

【关键词】

：

GP 紫杉醇周期阻滞细胞凋亡

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GP联合紫杉醇对胃癌细胞的协同抑制作用及其机制

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