胶质瘤细胞中GDNF基因启动子Ⅱ区高甲基化降低了CREB与之的结合能力

来源 :The 6th FAONS Congress and 11th Biennial Conference of CNS(第 | 被引量 : 0次 | 上传用户：falconcarmack

【摘要】

：

胶质细胞系源性神经营养因子(glial cell line-derived neurotrophic factor,GDNF)基因在胶质瘤细胞中异常高转录与其启动子Ⅱ区甲基化修饰变化有关,但其具体机制不清。有研究表明,GDNF 基因启动子Ⅱ区存在转录因子CREB 的2 个结合位点(分别位于增强子区和沉默子区),并且它们发生了不同程度的甲基化修饰改变。

【作者】

：

刘捷高殿帅

【机构】

：

徐州医学院基础医学院神经生物学教研室,江苏徐州 221009

【出处】

：

The 6th FAONS Congress and 11th Biennial Conference of CNS(第

【发表日期】

：

2015年3期

【关键词】

：

胶质瘤 GDNF CREB

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胶质瘤细胞中GDNF基因启动子Ⅱ区高甲基化降低了CREB与之的结合能力

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